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The importance of the inhibitory influence of Hp infection on circulating ghrelin is supported by our recent finding (60) that ghrelin content in the gastric corpus mucosa, a major source of this hormone in the stomach, was significantly higher than that in gastric antrum and that this corpus ghrelin concentration was markedly suppressed in Hp-infected shepherds before eradication therapy, whereas anti Hp-eradication therapy counteracted the inhibitory effect of Hp on gastric ghrelin content

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Statistical analysis T-tests were used to analyze the data of the metabolomics study