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Understanding the potential cardiovascular effects of tirzepatide is important for safe use

IL-8 has been shown to act on mucin post-translationally through increasing the levels of RNA-binding proteins to improve stability of the mucin transcripts ( MUC5B and MUC5AC gene expression in primary tracheal epithelial cells (Chen et al., 2003), and IL-17A caused an increase of MUC5AC in primary human bronchial epithelial cells through the NF-B enhancer of MUC5AC gene transcription (Fujisawa et al., 2011

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Patients with pre-diabetes (fasting glucose 100-125 mg/dL) or metabolic syndrome should be monitored closely