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Of note, G6pdh chon growth plates also showed an increase in the metabolic pathways glycine, serine and threonine metabolism and one carbon pool by folate, both of which can produce NADPH, suggesting that mutant chondrocytes try to compensate, albeit unsuccessfully, for the reduced NADPH generation by the PPP (Fig

g , Left, volcano plot showing the relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from Slc33a1 -knockout KP1 cells expressing a vector control or SLC33A1 cDNA

IP: Data curation, Methodology, Writing original draft