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Garelja ML, Hay D, Poyner DR, Walker CS

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Bulk RNA sequencing confirms that ECM types elicit significant changes in the expression of genes associated with MC pigmentation and differentiation Our data so far indicate that ECM composition modulates MITF localization and activity in MCs, suggesting that ECM components may influence MITF-regulated transcriptional programs

The trial began in March 2021 and concluded in January 2024, comprising a two-week screening period, a 12-week run-in period, and a 56-week treatment period, followed by a 26-week follow-up period