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The authors hypothesized that early life adversity may alter oral microbiome composition, which can shift to gut via saliva, potentially creating a pro-inflammatory state that increases vulnerability to PTSD following subsequent trauma exposure (Malan-Muller et al., 2022)

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The orforglipron 45 mg oral daily dose conferred weight change from baseline of 12.6% at 26 weeks and 14.7% at 36 weeks

Data were collected to estimate associations between GLP-1 receptor agonist use and the risk of differential reporting of thyroid cancer compared with other diabetes drugs, excluding insulin