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Consequently, the pharmacological inhibition of G6PD in cardiomyocytes is followed by a strong reduction in the GSH/GSSG ratio, increase in ROS production, and attenuated cardiomyocyte contractility via impaired calcium transport [165]

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VIP's diverse physiological functions offer potential therapeutic applications in various disease contexts

Examples of drugs that are in the latter class include the anti-malarial drugs dapsone and primaquine, as well as rasburicase which is normally used in the treatment tumor lysis syndrome in patients undergoing chemotherapy for hematologic cancers, but has also been used to reduce the hyperuricemia associated with gout