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Conclusion: Our findings suggest that melatonin effectively reduces oxidative stress

A three-year study of patients receiving regular Epithalon courses observed no adverse effects in the treatment group, with significantly reduced mortality compared to control groups

According to a recent systematic review, supplementation with vitamin A, C, B12, B3, B6, and D (with or without calcium), multivitamins, selenium, and calcium does not reduce the risk of overall or cardiovascular mortality.78 The US Preventive Services Task Force does not recommend the use of vitamins or multivitamins to prevent cardiovascular disease or cancer.78 Indeed, it advises against beta-carotene supplementation, as there is evidence that it might increase the risk of lung cancer and overall and cardiovascular mortality

[1] Furthermore, MBs antioxidant capability, directly scavenging free radicals or indirectly reducing their production, could contribute to protective effects against oxidative damage in tissues