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Inhibition of TLGST with the metal chelating agent EDTA suggested it as a metalloenzyme

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Seven more large-scale trials (the TRIUMPH program, over 5,800 people total) are still running and will release results throughout 2026

Shana E McCormack, Zi Wang, Kristin L Wade, Anna Dedio, Nicolette Cilenti, Julia Crowley, Franziska Plessow, Vaneeta Bamba, Jeffrey D Roizen, Yaoguang Jiang, Jack Stylli, Arjun Ramakrishnan, Michael L Platt, Karuna Shekdar, Michael J Fisher, Victoria L Vetter, Matthew Hocking, Rui Xiao, Elizabeth A Lawson, A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity, Journal of the Endocrine Society, Volume 7, Issue 5, May 2023, bvad037, 28