pCS induce increased production of ROS, increased expression of NADPH oxidase, and increased expression of pro-inflammatory factors MCP-1 and TNF- in human endothelial cells and aortic smooth muscle (84)
In contrast, AR-insensitive cell lines (e.g., DU-145, PC-3) also rely on ASCT2-mediated glutamine transport but are not directly modulated by AR signaling (33, 34)
However, the GLP-1 saga turns out, the fact that these drugs have popped up seemingly out of nowhere, and have generated such excitement, highlights the potential existing in the huge repurposed drug (drugs used in another condition than for which they are approved) market for these diseases
Una meta-analisi di 69 trial su GLP-1 AR non ha trovato unassociazione significativa con la neuropatia ottica ischemica (OR di MantelHaenszel 1,53