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Clinicians should be aware that even experienced radiologists will commonly label a small focus of hepatic metastasis, defined by contrast-enhanced CT scanning, as a hemangioma

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Following PH, the reduction in liver mass leads to hormonal changes that shift glucose metabolism towards glycogenolysis and gluconeogenesis in the remnant liver 44 and promote glucose utilization towards the pentose phosphate cycle to provide NADPH for lipid and DNA synthesis 45

131 The production of RONS increases the sensitivity of cells to genotoxic drugs by decreasing the activity of DNA-PKcs, hindering repair processes, and leading to the accumulation of DSBs