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The Critical Distinction for Supplement Evaluation Natural GLP-1 secretion: Triggered by meals, rises and falls within hours Rapidly degraded by DPP-4 enzyme (1-2 minute half-life) Transient receptor activation Physiological concentrations Pharmaceutical GLP-1 agonists: Continuous presence regardless of eating Engineered DPP-4 resistance (days-long activity) Sustained receptor activation Supraphysiological concentrations This difference is fundamental to understanding supplement claims