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Kovalzon and Strekalova, summarizing the field in 2006, were explicit: the link between DSIP and sleep had never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor, and the hypothesis of DSIP as a sleep factor was extremely poorly documented and still weak (Kovalzon & Strekalova, 2006)
Pietrogrande L, Raimondo E
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Investigators tapered or paused doses if intolerance developed (57.4% maintained maximum dose at week 68
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