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GLP-1 receptor agonists differ in their structural similarity to native human GLP-1, with some being modified peptides and others being exendin-4 analogues

Addressing these gaps will require a coordinated effort across clinical, regulatory and policy domains to ensure that the rapid expansion of GLP-1 use does not inadvertently expose vulnerable populations to harm

Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 are excluded