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Description

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

4-HNE also has a signaling function and is involved in the regulation of several transcription factors sensitive to OS, such as nuclear factor erythroid 2-related factor 2 (Nrf2), activating protein-1 (AP-1), NF-B, and peroxisome proliferator-activated receptors (PPARs) [8]