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Patients with PCOS may experience: reproductive abnormalities inflammation correlated with insulin resistance irregular or absent menstrual periods excess androgens (male hormones such as testosterone) polycystic ovaries resulting from the hormonal imbalances hirsutism (male-patterned hair growth) acne alopecia (thinning or loss of scalp hair) Additionally, both reproductive-age and older women with PCOS have an increased risk for conditions such as: impaired glucose tolerance type 2 diabetes mellitus elevated cholesterol or lipids increased abdominal adiposity obesity hypertension metabolic syndrome depression anxiety obstructive sleep apnea nonalcoholic fatty liver disease endometrial cancer cardiovascular disease Research suggests that medication alone might not be enough to address PCOS

Among those who have taken these drugs, about half (54%) including 53% of those with health insurance say it was either somewhat or very difficult to afford to pay for these drugs, including one in five (22%) who say it was very difficult, including a similar share of adults with health insurance (23%)

Established indirect modulators of GPX4