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Bi-weekly monitoring of absolute food intake and body weight showed a continuous increase in body weight across all DIO mice groups, including those treated with saline or fed a normal diet, indicating a sustained weight gain trajectory throughout the experimental period (Supplementary Fig

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Figure 1 2 Advantages of COF-based nanoplatforms for cancer therapy Unlike MOFs, COFs are typically constructed entirely from light elements linked by strong covalent bonds, rendering them inherently metal-free and generally free from the risk of toxic metal ion leaching, which contributes to their favorable biocompatibility (159, 160)