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However, other studies found increased CSF permeability and BBB disruption in a subset of patients infected with SARS-CoV-2 with elevated Q-albumin ratios that correlated with markers of inflammation 64

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FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)

Hormonal changes can lead to melasma, which causes dark patches on the face, as well as linea nigra, a dark vertical line on the belly, Dr