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Symptoms of vitamin B12 deficiency Some of the symptoms that can be caused by a lack of vitamin B12 include: Poor appetite Anemia Fatigue Weakness Numbness or tingling in the hands or feet Difficulty with balance Vitamin B12 deficiency can also contribute to depression, cognitive impairment, and dementia

An MJFF-funded Phase IIb placebo-controlled trial is currently examining the effects of intranasal glutathione on Parkinsons symptoms (both motor and non-motor)

This combination appeals to patients pursuing metabolic optimization, though clinical evidence for the synergistic benefit of inositol and choline alongside B12 remains limited

Effect of Methylene Blue on Red Cell Glutathione