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In individuals with type 2 diabetes, we observed that metformin (850 mg) ingested 30 min before an intraduodenal glucose infusion of 8.37 kJ/min (2 kcal/min) reduced the rate of glucose absorption by approximately 10%, and that the augmentation of GLP-1 secretion by metformin was related directly to the magnitude of inhibition of glucose absorption [9]

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These findings demonstrate that the aqueous humor profile of our identified metabolites reflects the characteristics of eyes with glaucoma and that these metabolites have the potential to support the diagnosis of glaucoma