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It is supposed to enter the TCA cycle as acetyl coenzyme A (AcCoA) after the oxidative decarboxylation by pyruvate dehydrogenase in normal metabolic status [60], but it turns out to be priorly transferred into LA in cancer cells and then shuttled to adjacent cells or stroma [61]
What additive benefit does the article's table give for dual therapy
Further longitudinal analyses in initially non-depressed subjects are needed to properly disentangle these two mutually non-exclusive scenarios
If symptoms of ketoacidosis occur, instruct patients to discontinue XIGDUO XR and seek medical attention immediately [see Warnings and Precautions (5.2)]
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