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To detect GLP-1R activity in the ex-vivo assay over a sufficient period of time for accurate half-life determination, the dose of the glycosylated variant in the PK stability experiment had to be increased to 40 mg/kg compared to 5 mg/kg for the non-glycosylated fusion

After you eat, it helps signal fullness to the brain, slows how quickly food leaves the stomach, supports insulin release when blood sugar rises, and helps reduce glucagon, a hormone that raises blood sugar

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