Additionally, the constrained confirmational changes during the simulation process are confirmed by the histogram of RMSD of various ligands (Fig
Heart failure is a common complication of obesity [61, 62], and clinical trials have shown that GLP-1 analogs, particularly tirzepatide, can improve cardiac function and reduce the risk of heart failure in people with obesity [63]
Second, they indicate minimal risk of allergic or hypersensitivity reactions, which can occur when immune responses develop against therapeutic peptides
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