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While these platforms are attractive in terms of safety, speed, stability and scalability, they carry a significantly higher risk of failure in clinical development as seen previously with other novel technologies 40

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A pilot study with metformin supplementation in 21 children and adolescents with PWS showed an improvement of the food-related distress and anxiety, evaluated by hyperphagia questionnaire, but no effects on body weight [19]

prausnitzii in feces, suggesting its potential regulatory role in intestinal immunity 81