This personalized approach ensures that patients receive tailored advice and treatment plans
Minor bruising at the injection site is a common side effect, similar to any injection therapy
At the molecular level, the prolactin gene contains two distinct promoter regions: the proximal promoter drives basal and regulates prolactin transcription, predominantly in pituitary lactotrophs, whereas the distal promoter is implicated in tissue-specific extrapituitary prolactin expression ( 2 receptors on lactotrophs, leading to the suppression of prolactin gene transcription and hormone secretion ( In addition to dopaminergic inhibition, prolactin secretion is modulated by a diverse array of hypothalamic factors including vasoactive intestinal peptides, serotonin, histamine, oxytocin, estrogen, thyrotropin-releasing hormone, dopamine receptor antagonists, and epidermal growth factor ( 2.2 Target site The biological effects of prolactin are mediated by the prolactin receptor (PRLR) and its canonical downstream JAK2/STAT5 signaling pathway
Secondary prevention of cardiovascular disease in high-risk patients diagnosed with cardiovascular disease (status post myocardial infarction or stroke, peripheral arterial disease), type 2 diabetes, or moderate to severe chronic kidney disease (CKD 4-5): in patients who cannot be diagnosed with FH according to Dutch criteria, although they have lipid disorders and do not achieve their LDL-C targets, according to the adopted guidelines (), and in whom all other standard therapies have failed (for at least 3 months) or are poorly tolerated, and/or there are contraindications to pharmacological treatment (adverse effects, complications, e.g
