They also used MD simulations to go further into the most changed phosphorylation location, serine 1782 (pS1782), and discovered that phosphomimetic alteration at this point lowers microtubule interaction (Grubisha et al., 2021)
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But here's what nobody tells you upfront: not all peptides work well nasally, bioavailability drops significantly compared to injection (often 30-50% vs 80-100%), and proper nasal technique makes the difference between success and complete waste of money
J Biol Chem 280:2530525312 Knollema S, Hom HW, Schirmer H, Korf J, Ter Horst GJ (1996) Immunolocalization of glutathione reductase in the murine brain