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It upregulates genes that code for collagen I, III, and IV while simultaneously suppressing genes associated with collagen degradation

Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

& Pachitariu, M

The accumulation of AGEs in patients with CKD is a result of oxidative stress and inflammation and can come from external sources such as diet and smoking (93, 94)