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0.5 mL of medium was removed from each well, and replaced with medium containing (i) FITC-insulin alone (concentration 100 L/mL), (ii) FITC-insulin with sodium chenodeoxycholate (1 mg/mL) or (iii) FITC-insulin with sodium chenodeoxycholate (2 mg/mL)

As we advance our understanding of these therapies and their clinical implications, it is crucial to balance the potential benefits with the risks of over-treatment

For instance, while it is generally believed that the etiology of diabetes in Southeast Asian diabetic patients points to especially poor insulin resistance [33], recent reports have indicated that a large sub-group of patients belong to an insulin-deficient phenotype [34]

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