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First we assessed proteolytically active proteasome subunits MECL1 , LMP2 and LMP7 required for assembly of the 20 S proteasome, protein degradation and amino acid recycling 25 , finding IGF-induced MECL1 downregulation in DU145 cells only and LMP2 downregulation in both DU145 and 22RV1 (Supplementary Figure S2A)

Or, to put it simply, muscle tissues use up more energy just existing so improving your lean muscle mass can help you burn more calories overall

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