NADPH-FSP1-CoQ10 pathway In the study of the ferroptosis-resistant cell line MCF7, the researchers screened the complementary gene for GPX4 deletion and found the apoptosis-inducing factor mitochondrial 2 (AIFM2) gene, which was initially found to induce apoptosis, and the researchers named it ferroptosis suppressor protein 1 (FSP1) [22]
This finding not only expands our understanding of the complexity of targeting glutamine transporters, but also provides new avenues and possibilities for customizing more precise treatment strategies that can be tailored to individual patients
Additionally, topiroxostat inhibits the ATP-binding cassette transporter G2 (ABCG2), which plays a key role in renal uric acid reabsorption and the secretion of uric acid from the intestines
Research should continue to integrate insights from genomics, microbiomics, neuroscience, and immunology through multi-omics and systems biology approaches to unravel the multifactorial nature of ASD