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Untreated PANC-1 cells displayed abundant JC-1 aggregates, indicative of healthy mitochondria, whereas treatment with vesicles resulted in predominantly JC-1 monomers, suggesting a loss of mitochondrial potential

The endoplasmic reticulum (ER) is a fundamental cellular organelle responsible for the newly synthesized proteins folding into their final 3-dimentional structures, post-translational modification, transportation, and quality control (Perri et al., 2016)

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MitoSiege-driven catalase collapse: a GSH-responsive, mitochondria-targeted COF prodrug for amplified chemodynamic therapy