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In the same work, cystine availability was lower in autochthonous PDAC tumours compared with subcutaneous tumours, supporting the relevance of anatomical location for the metabolic microenvironment

Remove the patch and gently pat the remaining essence into the skin

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Although these data suggest that GSH depletion per se, at least for a short period of time, is not sufficient to cause cell injury, a prolonged depletion of mucosal GSH leads to severe degeneration of intestinal mucosal epithelial cells, as shown in BSO-treated mice (Martensson et al, 1990)