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2.2 Eligibility criteria and relevant outcomes Studies which answered the most important question (regarding the efficacy and safety of subcutaneous semaglutide treatment on weight loss) and report the experiences of adults (age 18 years) with overweight or obese (BMI 25kg/m 2 ) who were prescribed semaglutide treatment for weight management in randomized controlled trials were included

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These effects are achieved through different mechanisms: 1) impairing of the ATP-gated P2X7 receptor (one on the main danger signal sensors on cells), that activates the NLPR3 inflammasome