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For BPC-157 specifically, the FDA reported limited and short human studies, a lack of adequate studies for several commonly used routes of administration, potential immunogenicity concerns, possible liver and clotting signals in animal studies, and three adverse-event reports, while noting that a cause could not be established

However, there is a risk to those experiencing any kind of infection or polycythemia vera (a condition marked by an abnormal increase of red blood cells)

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However, the analgesic effects of liraglutide were not observed in GSK3 (S9A) mice, indicating that liraglutide relieved diabetic pain by suppressing the NLRP3 inflammasome in microglia through GSK3 [84]