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Second, additive effect risks where two compounds affecting the same system (like glucose metabolism) can stack their effects beyond safe levels

In this study, a significant increase was observed after 12 weeks of treatment with metformin combined with semaglutide injections in the number of patients living with overweight/obesity and PCOS-related infertility who established regular menstrual cycles, with a higher maintenance rate than in the metformin-only group

They may recommend adjusting your dose, trying anti-nausea medication, or switching to a different medication