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Quick Answer: Tirzepatide and metformin can be safely combined for enhanced weight loss and glycemic control, with tirzepatide providing potent appetite suppression (15-22% weight reduction) and metformin offering insulin-sensitizing effects and modest additional weight loss (2-3%)

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Additionally, certain early signals including a possible association between GLP-1 use and elevated kidney cancer risk, as well as questions regarding long-term thyroid safety underscore the importance of individualised clinical assessment and ongoing medical supervision

T3 directly regulates hair follicle cycling, and even subclinical thyroid dysfunction, levels that fall within the "normal" range but sit at the lower end, can push follicles into premature telogen