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Animal experiments have shown that mice inoculated with lung cancer A549 cells treated with IGF-1 LR3 (0.2 mg/kg/d) showed a 2-fold increase in the number of lung metastatic nodules and a 30% reduction in survival time

With proper education and precautions, administering sermorelin at home is feasible and safe for the majority of patients who require it

447 Furthermore, astrocytic atrophy and reduced presence of astrocytes around synapses affects synaptic maintenance, glutamate homoeostasis, and K + buffering thus affecting neuronal excitability and limiting synaptic plasticity