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Alternatively, the GT1-7 mouse hypothalamic GnRH neuronal cell line was cultured with high glucose Dulbecco's Modified Eagle Medium containing 10% FBS, 1% penicillin-streptomycin, sodium pyruvate, and sodium bicarbonate, maintained at 37 C with 5% CO 2 at 5090% confluency, passaging 12 times a week