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Obesity is a network disease involving appetite regulation, reward signaling, gut-brain hormones, and energy expenditure pathways

The composite endpoint included the need for retinal photocoagulation, treatment with intravitreal agents, vitreous hemorrhage, or diabetes-related blindness

Carlos-Bregni R, Contreras E, Netto AC, Mosqueda-Taylor A, Vargas PA, Jorge J, et al: Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature and immunohistochemical analysis