After a normalization procedure with ProgenesisQI, which we also previously described, we determined ions estimated to have derived from the eye drop-delivered drugs, as well as the metabolites of these drugs and their additives (Supplementary Table 1)
This may help researchers improve the effectiveness of their experiments and dig deeper into exploring how DSIP works
Among the key genes implicated in this process are tyrosinase (TYR), tyrosinaserelated protein 1 (TYRP1), tyrosinaserelated protein 2 (TYRP2), microphthalmiaassociated transcription factor (MITF), paired box gene 3 (Pax3), SRYbox transcription factor 10 (Sox10), melanocortin 1 receptor (MC1R), tyrosine kinase receptor (cKit), Plexin C1 (Plexin C1), MelanA (MelanA), premelanosome protein (Pmel17), and the receptor for hepatocyte growth factor (MET)
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