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some prefer twice daily for split dosing Cycle length: 4-8 weeks, with breaks between cycles For joint-specific issues: Injection closer to the affected area may provide more targeted effects, though systemic administration also works

GLP-1 receptor agonists begin exerting physiological effects at different rates depending on the specific medication, though the timeline for clinically meaningful outcomes varies by therapeutic goal

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This review systematically retrieved relevant literature published from 2015 to 2025 from databases including Web of Science and PubMed, using the keywords saponins, tumors, and combination therapy. Building upon this foundation, this review comprehensively summarizes the antitumor effects of saponins against various malignant tumors and their underlying mechanisms, while exploring their synergistic therapeutic potential in combination with chemotherapeutic agents