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The copper ion (Cu2+) is an essential cofactor of lysyl oxidase, the enzyme that catalyzes the cross-linking of collagen and elastin, ensuring the three-dimensional structure and mechanical resistance of the extracellular matrix

Psychiatry 26 , 41914204 (2021)

This is one of the key drivers of mitochondrial failure, accumulation of irreparable DNA damage and cellular aging across tissues

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