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Controlled human trials exist, but they're limited in size, focused mostly on topical cosmetic use, and usually last only a few weeks or months. That means a lot of the exciting claims, especially around gene expression, systemic repair, and anti-aging effects, haven't been confirmed in large-scale human studies

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Our ability to create new collagen decreases over time, and breastfeeding women are especially susceptible to the risks of inadequate collagen availability

Transdermal gels and creams (both FDA-approved and compounded), vaginal preparations for genitourinary symptoms, sublingual troches, and injectable estradiol are all available