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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)
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A dose of 8mg of the drug is recommended at the start of the prodrome, in combination with other abortive medications, such as triptans and anxiolytics
doi: 10.1016/j.bbi.2021.02.011 119 FisslthalerBFlemingI
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