It is of concern that the efficacy of MSCs is greatly limited by the local inflammatory microenvironment following SCI
Vazeille E, Codran A, Claustre A, Averous J, Listrat A, Bechet D, Taillandier D, Dardevet D, Attaix D, Combaret L (2008) The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy
The first is 5 mg SC daily for 20 consecutive days, repeated twice yearly (spring and fall, often timed to other peptide cycles)
These are considered dangerous activities that may impact the recovery process negatively, delaying the healing process