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Consistent with this, our preclinical work uncovered that TMAO primed renal fibroblasts for conversion to myofibroblasts, the primary collagen-producing cells in the kidney 46 , and contributed to renal fibrosis, a hallmark of kidney damage irrespective of the underlying cause that significantly contributes to eGFR decline 46

The commenter stated that the Overall Hospital Quality Star Rating system already oversimplifies hospital quality and that further emphasizing a single domain, particularly through penalties, risks distorting the meaning of the rating and diminishing its usefulness to patients

PMID: 10642559

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