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This type of pain may worsen with movement or prolonged activity but can also be present at rest

The research picture is the opposite: slow, cumulative, and subtle, with the biology plausibly running weeks ahead of anything observable

9 Conger AM, Randall DJ, Sperry BP, Kuo KT, Petersen R, Henrie AM, Kendall RW, Bisson EF, Teramoto M, Martin BI, Burnham TR

Conversely, glutathione reductase (Gsr), heme oxygenase 1 (Hmox1), glucose transporter member 5 (Glut5) and lipoprotein lipase (Lpl) were increased during the dark, or active period, suggesting that microglia have increased nutrient uptake during the active period