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All families whose children participated and completed the 90-days trial period received a signed form by the principal investigator with instructions about how to contact the manufacturer of CRWP (Immunocal, Immunotec Inc., Montreal, Canada) to obtain the supplement quarterly at no extra cost for up to 3 years (this was voluntary if the parent signed and gave consent)

That decision should be based on individual self-determination with risk/benefit analysis and informed consent

& Frishman, D

Subsequently, during proliferative and remodeling phases, TIMP expression increases in coordination with new matrix deposition, preventing premature degradation of nascent collagen and elastic fiber networks