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Inhibition of ceramide synthesis using myriocin, an inhibitor of serine palmitoyltransferase, prevented insulin resistance and attenuated ceramide contents in fat-fed mice [127,128]

Our data suggest that GCLM KO mice have higher capacities for ethanol and acetaldehyde clearance, which may contribute to the protective phenotype

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Even with less-than-expected weight loss, patients with lipedema should still be considered candidates for bariatric surgery as several procedures (e.g., laparoscopic gastric bypass and sleeve gastrectomy) have shown weight-independent benefits on glucometabolic outcomes, especially prediabetes and diabetes, and cardiovascular risk