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ROS produced by NADPH oxidase activity was related to chemokine (CCL2, CXCL8, and CXCL10) production, and it was inhibited by the treatment of astrocytes with NAC or NADPH oxidase inhibitors [58]

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New England Journal of Medicine , 367(7), 616-624

The relative bioavailability of higher doses has been reported to be even lower [108]