These findings were supported by the relaxation of large vessels (ex vivo), mainly by acting on vascular endothelial cells but also on vascular smooth muscle cells, increasing NO production and migration of endothelial cells, activating the signal pathways of Src, Cav-1, and eNOS, and reducing proteinprotein interaction between eNOS and Cav-1 [121,122]
The peptide is non-selective across melanocortin receptor subtypes, which is why nausea (MC3R/MC4R), flushing (MC1R/MC5R), and spontaneous erections (MC4R) occur alongside tanning
We specifically thank Rick Lundberg, Richard Fisher, Lauren Evans, and Tonya Gilbert from Eikonizo Therapeutics for sponsoring the NULISA assays
Ozempic and Rybelsus are indicated primarily for the management of type-2 diabetes, while Wegovy is approved mainly for weight management